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Full spectrum CBD oil tincture for sale with 2mg THC and 50mg CBD per serving. Certified organic, vegan. Sleep, stress, aches and pains support. CBD oil has skyrocketed in popularity thanks to its purported calming effects. Here are nine ways studies suggest CBD oil could benefit your health. Last month, a U.S. Food and Drug Administration advisory panel unanimously recommended approval of the CBD medication Epidiolex to treat two rare forms of childhood epilepsy.

Full Spectrum CBD Oil

We believe you deserve the best quality of life. That’s why we provide the highest quality full spectrum CBD oils in America, building on 250 years of Kentucky’s unparalleled hemp tradition. Available in 375mg, 750mg, and 1,500mg varieties, our USDA certified organic CBD tinctures are carefully extracted to obtain CBD, minor cannabinoids, and up to 0.3% THC – the way nature intended.

Full Spectrum CBD Oil for Sale

Full Spectrum CBD Oil Tinctures

Whole Flower CBD Oil: For nighttime, our Whole Flower CBD Oil contains the highest legal level of THC, minor cannabinoids, flavonoids, and terpenes.

Max THC | Nighttime | CBD 22:1 THC*

Distilled CBD Oil: For daytime, our Distilled CBD Oil is pure and smooth, with just the right touch of minor cannabinoids and THC that won’t slow you down.

Low THC | Daytime | CBD 27:1 THC*

Just like you, we value the importance of a good night’s sleep, and waking up feeling rested the next morning. Our Whole Flower CBD Oil may help you relax and ease your way into a peaceful, full night’s rest, without causing any grogginess or a hangover the next morning.

Why does the Distilled CBD Oil contain a small amount of THC? Larger amounts of THC can result in drowsiness or sleepiness that most folks don’t want to experience during the day.

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Make sure you never run out of your favorite CBD oil! Full Sprectrum CBD products work best when you take them consistenty over time, thats why we have made it easy.

Full spectrum CBD oil FAQ’s

What is full spectrum CBD oil?

Full spectrum CBD is a popular wellness supplement that is extracted from hemp plants which contain a wide range of cannabinoids like CBG, CBN, CBC, THC, and CBD. Many CBD oil tinctures or organic CBD oils are made with 99% pure CBD isolate or broad spectrum CBD, which have been process to remove the THC and other full spectrum hemp compounds. The best full spectrum CBD products have been shown to produce a more profound entourage effect than THC-free CBD products.

Why choose USDA certified organic CBD oil?

A CBD oil tincture that has been certified organic by the USDA must be verified by a third party to be grown without any synthetic fertilizers, pesticides, or other non-organic materials. Additionally, an organic crop rotation is required to replenish vital nutrients back into the soil naturally, instead of using synthetic fertilizers. This ensures that every cannabis plant will be free of any contaminants, and that the farmland used to harvest it will be sustainable for the years to come. Simply put, organic cannabis is both better for your body and better for our planet.

What does Flower-Only™ mean?

Full spectrum cannabinoids are produced in the flower of the cannabis plant, not the stems, leaves, or stalk. That’s why we only include hemp flowers in our CBD extraction process, which creates a higher quality full spectrum CBD oil tincture that is free of unneccessary wax and chlorophyll. That means we don’t need to add cover flavors or preservatives, either.

Can full spectrum CBD tinctures get me high?

By law, full spectrum CBD products must remain below 0.3% THC, which is not enough THC to make someone feel high. However, studies show that having THC present in trace amounts in cannabis extracts may help to provide a more powerful entourage effect. That’s why we use an extraction process that preserves every bit of cannabinoid, terpene, and flavonoid content that our high CBD cannabis plants naturally produce.

How much CBD oil should you take?

The answer to how much CBD you should take depends on factors like body weight, metabolism, and why you’re taking it. To keep things simple, start at our recommended dosage of 25mg per day and slowly work your way up. Track your daily progress in a journal to keep up with how your body reacts over time.

How long does CBD take to work?

How long CBD takes to work depends on your wellness goals and what you’d like to achieve, as well as the delivery method of your CBD, such as CBD edibles or CBD gummies vs sublingual CBD. Many people report feeling the effects of sublingual CBD in just 15-20 minutes. Those who are suffering from everyday worries may experience results quicker than someone using it for muscle and joints. Generally speaking, it takes 2-3 weeks for CBD to begin to really work. However, every human body will metabolize hemp derived CBD products differently.

Is it legal to send CBD in the mail?

Yes! The Farm Bill of 2018 legalized any full spectrum cannabis product that contains less than 0.3% THC. All of our products are made with fully legal and compliant hemp that has been overseen by the Kentucky Department of Agriculture. All of our products ship via USPS, a federal organization that openly supports hemp-derived CBD shipments. For questions about shipping and returns, visit our FAQ’s page.

CBD Oil Buyers Guide

Is a CBD oil tincture different from CBD oil?

The terms CBD oil vs CBD tincture can be confusing because both products are housed under the orally consumable, sublingual liquid category. Both a CBD tincture and CBD oil can be placed under the tongue and absorbed through the mucous membranes in your mouth, directly into the blood stream. A traditional tincture is made using alcohol to suspend the hemp extract instead of a carrier oil like organic MCT oil, or medium chain triglyceride oil. Full spectrum cannabinoids are fat soluble, and bind well with medium and long chain oils that contain a high level of triglycerides. Because of their sublingual applications, these terms are often used interchangeably. The best way to know exactly what you’re buying when shopping for a hemp-based cannabidiol product is by reading the label carefully and looking at the third party lab tests.

Is hemp oil the same as CBD oil?

When assessing hemp oil vs CBD oil, proceed with caution. Because of the potential health benefits of CBD, some companies have decided to try and make a quick buck by selling fake cannabidiol hemp oil disguised as CBD oil. Generally, these products are a blend of carrier oil mixed with hemp seed oil, which does not contain any CBD content. The effects of CBD won’t be felt when taking products that are made with cannabis sativa seed oil, as CBD comes from the flower of the mature cannabis plant, and not the seed.

Do you need a prescription to buy Full-spectrum CBD oil?

No! Nonprescription cbd products are the norm. That being said these products are not meant to be used by children. If you have any health conditions that you believe maybe of concern in taking full spectrum cbd oils, please contact your doctor before using CBD oil.

What is the endocannabinoid system?

The endocannabinoid system is a group of cannabinoid receptors that bind with compounds already produced in the human body. These compounds are called endocannabinoids, and the cannabis plant just so happens to produce them as well. These are called phytocannabinoids. The ECS is in charge of regulating balance and homeostasis in many critical processes like sleep, stress, and muscle and joint function. By taking a sublingual product with both CBD and THC present, like our high quality plant-based cannabinoid oils, we are able to naturally supplement our endocannabinoid system.

Is full spectrum CBD better?

Early research suggests that hemp products with a full spectrum of cannabinoids may provide a more powerful entourage effect than broad spectrum CBD oil or CBD isolate. This increased interaction is now being referred to as the entourage effect, which shouldn’t be confused with getting high or any other psychoactive effects. Even though full spectrum hemp products may contain THC at no more than 0.3%, this is not enough to make someone feel high from taking a CBD tincture.

Are there side effects from CBD?

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Not enough clinical trials have been performed to be able to report any potential side effects of CBD. At this time, more research is needed on the side effects of the highest quality cannabidiol CBD tincture. If you’re worried about the side effects of organic CBD oil, try using our full spectrum certified organic CBD topicals. They’re perfect for on-the-spot relief from muscle and joint discomfort!

How do you take CBD oil?

Taking CBD is easy! Unscrew the child safe dropper and push the dropper bulb to fill the applicator to your desired dose. Start slow at a smaller serving size until your body can properly adjust to the full spectrum hemp plant compounds in your wellness routine. After drawing up your desired serving size, place the dropper applicator under your tongue and administer the sublingual oil. Allow the CBD oil tincture to absorb into the mucous membranes in your mouth for at least 60 seconds. Coat the inside of your mouth with any oil that remains in order to absorb as much cannabinoid content as possible. Many people choose to take their CBD tincture both in the morning and at night, depending on their desired results.

Can CBD oil with THC make you fail a drug test?

The best full spectrum CBD products contain a wide range of major and minor cannabinoids, terpenes, flavonoids, and fatty acids. That being said, it’s certainly possible that ingesting our hemp-derived CBD products, like organic CBD oils, could cause you to fail a drug test due to trace amounts of THC. If you’re worried about taking full spectrum CBD products and getting drug tested, make sure to speak with your healthcare provider before use.

Can you overdose on CBD?

If you take too much CBD oil, you might notice that you feel tired or sleepy, or a slightly upset stomach. However, taking too much CBD oil will not result in an overdose or other harmful reaction – you cannot overdose on CBD. To be safe, start with a small introductory dose and increase slowly as needed.

How is hemp different from marijuana?

To understand the difference between hemp vs marijuana, you’d need a lab test! That’s because hemp and marijuana look, smell, and taste identical. The only difference is that hemp is a cannabis plant that contains less than 0.3% THC, which makes them legal across all 50 states. If you saw a field of hemp next to a field of marijuana, you’d never know which was which!

Does Full-spectrum CBD oil expire?

CBD oil does expire, but not all CBD products are created equal. Most CBD companies use preservatives and flavoring to make their inventory shelf stable for several years. At Cornbread Hemp, we believe in serving you the highest quality cannabis products available. That means no preservatives, flavoring, or fillers. As a result, the shelf life of our products is shorter, but the impact is much greater!

How does CBD oil make you feel?

Scientific studies are in early phases, and not eneough research has been performed to definitively say how CBD oil will make you feel. However, anecdotal reports suggest that CBD oil may help support a sense of calm and relief from anxiety, promoting a healthy sleep cycle, and relief from everyday aches and pains.

Best CBD Oil for Sale

The desire to improve the overall quality of life is the main reason that our full spectrum CBD oils have such a huge following. But is CBD oil the best CBD product? To set the record straight, every CBD product will be helpful in potentially aiding your physical and mental comfort. Cornbread Hemp’s full spectrum CBD oil is perfect for both beginners and experts. Without having to risk your health using vaporizers and smoking, using a full spectrum CBD oil tincture is the quickest and safest form of CBD uptake.

If oil isn’t your thing, check out our best-selling full spectrum CBD gummies. If you prefer no taste or mess, try our full spectrum CBD capsules!

How to get the most out of our CBD oils

Purchasing CBD oil for the first time can be daunting. Finding a high quality and effective CBD oil that works for you is always the top priority. But even for those who are experienced with CBD, here are a few tips to help make sure your experience is the best yet! Despite how customized Cornbread Hemp CBD oils are, there are some choices you’ll want to consider when optimizing your CBD wellness experience. Here are some tips and tricks to keep in mind.

Always look for full spectrum.

Opting for full spectrum CBD products rather than broad-spectrum CBD or CBD isolate is the best choice if you want to experience the best of the entourage effect of cannabinoids. The entourage effect happens when minor cannabinoids and terpenes are naturally included, and are not being removed during the process of CBD extraction. Simply put, the health effects of CBD may possibly be much greater when you choose a full spectrum hemp extract. One thing to note, however, is that the THC levels in any Cornbread Hemp full spectrum CBD product will not cause you to feel intoxicated, as long as you follow the recommended dosage.

Practice sublingual administration.

As much as possible, you want to shorten the process of CBD absorption in your system. Like with other herbs, you may choose to take CBD oils sublingually. This means you allow the CBD oil to sit under your tongue for at least 30 to 60 seconds, in order to permeate the oral epithelium before swallowing. Full spectrum CBD is a highly lipophilic molecule, so sublingual administration may be your quickest and safest bet.

Send CBD oils to your loved ones, even if they’re miles away.

Did you know that Cornbread Hemp full spectrum CBD oils can be transported via air or mail? Our CBD oils are TSA and USPS compliant. However, even though the Farm Bill of 2018 made hemp legal in all 50 states, it’s best to check the destination of where you’re heading or sending a package, to make sure it’s cannabis-friendly.

The Cornbread Difference

Extracting only from the flower of the hemp plant. Hemp flowers are where the highest concentration of CBD and minor cannabinoids come from. Specifically, CBD and THC are abundant in the trichomes, the small resin-like hairs in mature hemp flowers. Cornbread Hemp carefully uses only the hemp flowers to ensure the highest quality and the best full spectrum CBD oil.

Kentucky’s massive limestone bed is perfect for growing hemp. Your full-spectrum CBD oil should come from Kentucky, the state with the most fertile soil and water known to man. A prehistoric ocean turned into a limestone rock bed, our home state is the best in the US for growing the healthiest cannabis plants, which make the best full spectrum CBD oil. Just like our co-founder Jim Higdon puts it, “Kentucky is to hemp what the Napa Valley is to wine”.

Organic CBD products should be USDA-certified. It’s easy to say a CBD product is organic or all natural, but who keeps watch? How do you, a consumer, ensure this? At Cornbread Hemp, we went the extra mile to get certified organic by the United States Department of Agriculture (USDA). The coveted organic seal confirms that we never use pesticides or other synthetic materials at any point during the life of our precious cannabis plants. From organic farming to hand-harvesting and using only the flower of the hemp plant, our freshness and quality remain until the last drop.

Cornbread Hemp Flower-Only Full-spectrum CBD oil vs Other CBD Oils

Despite the market getting saturated with many different CBD oils and CBD tinctures, Cornbread Hemp’s Flower-only™ Full Spectrum CBD Oil is undoubtedly the number one choice. Based on the Cornbread Mafia, we aim to legally bring the therapeutic benefits of CBD and THC to every single human in the United States. You’ll never find low quality ingredients or subpar manufacturing at Cornbread Hemp. We stick to what we do best — delivering the cannabis plant in its most natural form, using premium ingredients, and exceeding every customer expectation. Ask our experts or your local health clinician how you can incorporate Cornbread Hemp’s CBD oils into your routine today!

How much CBD per bottle?

Cornbread Hemp offers three different strenghts of CBD Oil. The 370 mg bottle contains 2 mg of CBD per dose. The 750 mg bottle contains 25 mg of CBD per dose. The 1500 mg bottle contains of 50 mg of CBD per dose. All of these products are thrid party lab tested.

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Choose a CBD brand that values customer service.

Cornbread Hemp has thousands of positive reviews on our website, unlike a lot of other online cannabis dispensaries. Not only is this because of we have the best full spectrum CBD oil and other CBD products, but it’s also because we sincerely value customer approval. In fact, we offer a CBD oil subscription so you may easily replenish your stock each month. Additionally, we offer a 30-day money back guarantee on all orders. If you are unsatisfied for any reason, let us know and we will refund your entire purchase, no questions asked.

CBD Oil: 9 Science-Backed Benefits

Dr. Bindiya Gandhi is an integrative medicine physician with expertise in functional and holistic medicine based in Atlanta, Georgia.

Commissions we earn from partner links on this page do not affect our opinions or evaluations. Our editorial content is based on thorough research and guidance from the Forbes Health Advisory Board.

Cannabidiol, or CBD, is a chemical compound found in the cannabis sativa plant. When applied topically or consumed through smoke inhalation or edible consumption, CBD interacts with neuroreceptors in your endocannabinoid system, which sends signals between your cells to help regulate your movement, mood, homeostasis and immune system.

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CBD is often extracted from the cannabis sativa plant in oil form and mixed with an inert carrier oil like hemp seed oil for consumption. In fact, of the 60% of U.S. adults who report having used CBD before, 55% of them use CBD oils and tinctures specifically, according to a recent Forbes Health survey of 2,000 U.S. adults conducted by OnePoll.

CBD research is growing, too. Here are nine ways studies suggest CBD oil could benefit your health.

1. Offset Anxiety and Depression

CBD’s ability to calm is perhaps its most popular effect and the reason its use is so widespread. A 2017 study in the Brazilian Journal of Psychiatry tested the anxiety levels of 57 men in a simulated public speaking test. Some received a placebo while others received either 150 milligrams, 300 milligrams or 600 milligrams of CBD before their speeches. Those who received 300 milligrams of CBD experienced significantly reduced anxiety during the test compared to those who received the placebo. Interestingly, participants who received either 150 or 600 milligrams of CBD experienced more anxiety during the test than the 300 milligrams group.

Meanwhile, at least one study in mice revealed CBD had effects similar to the antidepressant imipramine. Human trials are needed, though, to confirm whether CBD can induce this same antidepressant reaction in our bodies.

2. Treat Select Epilepsy Syndromes

In some instances, CBD can be used to treat epileptic seizures.

In 2018, the Food and Drug Administration (FDA) approved the use of CBD under the brand name Epidiolex to treat seizures resulting from Lennox-Gastaut syndrome and Dravet syndrome—two rare forms of epilepsy—in patients at least 2 years old.

Three well-vetted studies provide the basis of support for the FDA’s decision. In these trials, 516 patients with Lennox-Gastaut syndrome or Dravet syndrome received either Epidiolex or a placebo. Epidiolex, when taken along with other prescribed medications, decreased the frequency of participants’ seizures compared to the placebo.

3. Reduce PTSD Symptoms

In a small 2018 study in the Journal of Alternative and Complementary Medicine, 11 people with post-traumatic stress disorder (PTSD) received CBD along with routine psychiatric care for eight weeks in an outpatient psychiatric clinic. Ten of the 11 experienced a decrease in their PTSD symptoms. CBD was generally well tolerated, the researchers write.

Margaret Rajnic, a doctor of nursing practice experienced in medical cannabis and CBD, emphasizes the importance of using therapy in tandem with any type of cannabis or CBD for PTSD. “There is an amount of therapy that is needed for PTSD,” she says. “But CBD will give you that little bit of decreased anxiety.”

Four other human trials from 2012 to 2016 suggest CBD reduces PTSD symptoms, although some include THC, or tetrahydrocannabinol, the main mind-altering element in cannabis. When THC and CBD work together, they create what’s called an “entourage effect,” complementing each other’s benefits and potency. For example, taking the same dose of THC and CBD together tempers the “high” from THC, while just a little THC paired with more CBD enhances the effects of the CBD.

4. Treat Opioid Addiction

Some studies—both preclinical animal and human clinical trials—suggest CBD could be used to help treat people who are dependent on opioids.

In one such study, researchers administered CBD to people with heroin use disorder. Over the course of a week, CBD significantly reduced heroin users’ cue-induced cravings, withdrawal anxiety, resting heart rate and salivary cortisol levels. No serious adverse effects were found.

Other studies find CBD helpful in reducing various psychiatric and medical symptoms like anxiety, insomnia and pain in patients with substance use disorders, indicating that CBD may be an effective treatment for opioid addiction. However, further studies are necessary.

5. Alleviate ALS Symptoms

Amyotrophic lateral sclerosis (ALS) is a disease that causes nerve cells in the brain and spinal cord to deteriorate, resulting in loss of muscle control that worsens over time. It’s not yet understood exactly why ALS occurs, although it can be hereditary in some cases. There’s no known cure, and there are only two FDA-approved medications to help treat ALS symptoms.

Research suggests people with ALS can benefit from the entourage effect created by the combination of THC and CBD, similar to people with PTSD. In a 2019 study, patients received a combination of THC and CBD in varying doses depending on their needs and preferences. Those with mild, moderate or severe spasticity (muscle tightness and stiffness) due to ALS reported high levels of satisfaction with the treatment, and those with moderate to severe spasticity reported higher satisfaction rates than those with mild spasticity.

6. Relieve Unmanageable Pain

In 2005, Canada approved the use of Sativex, an oromucosal (absorbed in the lining of the mouth) spray with equal proportions of THC and CBD, for the treatment of multiple sclerosis-related central neuropathic pain. In 2007, Canada approved the medicine’s use again for cancer pain that proved unresponsive to other medications.

Meanwhile, continued studies in the U.S. indicate CBD is effective in treating chronic, non-cancer pain. In one 2020 study, researchers administered CBD topically to a group of patients with symptomatic peripheral neuropathy (a result of brain nerve and spinal cord nerve damage) while another group with the same condition received a placebo. Results showed a significant reduction in intense, sharp pains and cold, itchy sensations in those who used the topical CBD compared to those who used the placebo. No participants reported adverse side effects.

When introduced topically, CBD oil doesn’t affect the systemic issue as it might if it were introduced directly into the bloodstream. Instead, topical CBD is more localized and treats pain in a certain area. Since it’s more direct, it may have a more pronounced effect.

7. Ease Diabetic Complications

For starters, tests on human cells found that CBD helps reduce the effects of high glucose levels on other cells in the body, which typically precedes the development of diabetes and various complications. Researchers concluded that with further studies, CBD could have significant benefits when used in patients with diabetes, diabetic complications and plaque buildup in artery walls.

In another small study, 13 patients with type 2 diabetes who weren’t on insulin treatment were given both CBD and a placebo (in lieu of insulin). Researchers found CBD decreased their levels of resistin (which causes resistance to insulin, the protein that regulates sugar levels) and increased their levels of glucose-dependent insulinotropic peptide (a hormone that ensures a sufficient release of insulin from digested food) compared to their baselines before they started the test. These results suggest CBD could be a natural treatment for diabetes by helping the body regulate insulin-related hormone levels.

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8. Protect Against Neurological Disease

Preclinical and clinical studies show that CBD has antioxidant and anti-inflammatory properties. Researchers deduce these characteristics can provide significant neuroprotection, or protection against numerous pathological disorders.

Several preclinical studies suggest CBD can produce beneficial effects against Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. Huntington’s disease and cerebral ischemia were also tested, although significant positive results were not recorded. Further clinical studies are needed to confirm CBD’s benefits when used as a treatment for these disorders.

9. Inhibit Arthritis Symptoms

Arthritis involves the deterioration of the tissues in and around your joints. There are several types of arthritis, and symptoms include pain, stiffness and loss of motion. Arthritis treatment usually targets pain relief and improved joint function.

A 2006 study found that Sativex—a CBD-based botanical drug approved in the United Kingdom in 2010—promoted statistically significant improvements in quality of sleep, pain during movement and pain at rest in patients with rheumatoid arthritis when compared to a placebo. It was the first controlled trial of Sativex as a treatment for rheumatoid arthritis, involving 58 patients. CBD was found to have a pain-relieving effect, as well as an ability to suppress disease activity.

In 2018, in a study of more localized treatment, researchers administered a synthetic CBD gel in either 250-milligram or 500-milligram doses daily or a placebo to patients with knee pain due to osteoarthritis. Patients also stopped taking any other anti-inflammatory medications or painkillers, with the exception of acetaminophen, before and during the study period.

The results were interesting, although not entirely conclusive. On one hand, those treated with CBD did not experience much change in pain when compared with placebo patients. On the other hand, there were statistically significant differences between the group receiving the 250-milligram dose and the placebo group when measuring the average weekly improvement of their worst pain levels and their WOMAC (Western Ontario and McMaster Universities Arthritis Index) physical function rating. Additionally, men seemed to benefit from CBD more significantly than women in this test.

CBD Oil: All the Rage, But Is It Safe & Effective?

MONDAY, May 7, 2018 (HealthDay News) — Cannabidiol (CBD) oil has become the hot new product in states that have legalized medical marijuana.

The non-intoxicating marijuana extract is being credited with helping treat a host of medical problems — everything from epileptic seizures to anxiety to inflammation to sleeplessness.

But experts say the evidence is scant for most of these touted benefits.

Worse, CBD is being produced without any regulation, resulting in products that vary widely in quality, said Marcel Bonn-Miller, an adjunct assistant professor of psychology in psychiatry at the University of Pennsylvania School of Medicine.

“It really is the Wild West,” Bonn-Miller said. “Joe Bob who starts up a CBD company could say whatever the hell he wants on a label and sell it to people.”

Cannabidiol is extracted from the flowers and buds of marijuana or hemp plants. It does not produce intoxication; marijuana’s “high” is caused by the chemical tetrahydrocannabinol (THC).

CBD oil is legal in 30 states where medicinal and/or recreational marijuana is legal, according to Governing magazine.

Seventeen additional states have CBD-specific laws on the books, according to Prevention magazine. Those are Alabama, Georgia, Indiana, Iowa, Kentucky, Mississippi, Missouri, North Carolina, Oklahoma, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Wisconsin and Wyoming.

Strong Evidence for Treating Epilepsy

Only one purported use for cannabidiol, to treat epilepsy, has significant scientific evidence supporting it.

Last month, a U.S. Food and Drug Administration advisory panel unanimously recommended approval of the CBD medication Epidiolex to treat two rare forms of childhood epilepsy.

“That’s really the only area where the evidence has risen to the point where the FDA has said this is acceptable to approve a new drug,” said Timothy Welty, chair of the department of clinical sciences at Drake University’s College of Pharmacy and Health Sciences, in Des Moines, Iowa.

For the rest of CBD’s potential uses, there is simply too little evidence to make a firm conclusion.

For example, some human clinical trials suggest that CBD could be effective in treating symptoms of anxiety, particularly social anxiety, Bonn-Miller said.

This is the potential use for CBD with the most evidence after usefulness in epilepsy, but “there’s a decent gap between those two,” he said.

“There have been clinical trials in adults, but a lot smaller than the epilepsy studies that have been done in kids,” Bonn-Miller said.

CBD’s usefulness as an anti-inflammatory medication is the next most promising, but those results come mostly from animal studies, experts said.

Most Other Uses Largely Unproven

The rest of the potential uses — as an antipsychotic, antidepressant or sleep aid “have all been studied in animals, with only one or two examples of studies in humans,” Bonn-Miller said.

And Welty said the studies that have featured humans for these other CBD uses have either been case reports or studies that did not compare results against a control group that did not use the oil.

“There’s no control, so it’s basically how do you know if we’re dealing with the true effect of the drug or just simply a placebo effect because somebody thinks they’ve been given a drug that will be beneficial?” Welty said.

There also are concerns about both the quality of CBD oil being produced and its potential side effects, the experts added.

Lack of Regulation Also Concerning

Because of the legally murky nature of marijuana, the FDA has not stepped in to regulate products like CBD oil, Bonn-Miller said. States are struggling to put regulations in place, but they don’t have the deep pockets of the federal government.

Meanwhile, a 2017 study led by Bonn-Miller found that nearly 7 of 10 CBD products didn’t contain the amount of marijuana extract promised on the label.

Nearly 43 percent of the products contained too little CBD, while about 26 percent contained too much, Bonn-Miller said.

“CBD is kind of a tricky drug because it’s not very well absorbed orally,” Welty explained. “Less than 20 percent of the drug is absorbed orally. If it isn’t made in the right way, you may not be getting much drug into your systemic circulation.”

Worse, about 1 in 5 CBD products contained the intoxicating pot chemical THC, Bonn-Miller and his colleagues found.

“That’s a problem because THC can increase anxiety. It can actually make seizures worse. Those are the sorts of things you need to be careful about,” Bonn-Miller said.

“If I were a consumer, purchasing it for myself or my kid, I would want to test it so that I knew what it actually had in it, because I couldn’t trust what was on the label,” Bonn-Miller concluded.

Potential Interactions With Other Meds

Studies on CBD also have raised concerns about possible interactions with other drugs.

For example, epilepsy studies found that “there were very clearly increases in the blood levels of some other anti-epileptic drugs when people were on CBD,” Welty said.

This could mean that people taking anti-epilepsy drugs alongside CBD will need to adjust their dosage downward to avoid side effects, Welty noted.

There also is some indication that CBD might harm the liver. About 10 percent of people taking CBD in studies had increases in liver enzymes, which would indicate possible liver damage, Welty said.

“About 2 to 3 percent of individuals taking CBD actually had to discontinue because their liver enzymes went so high it was of concern to the people running the study,” he said.

Welty recommends that people interested in CBD seek out a doctor who has read up on the extract and its potential uses.

“My bottom-line advice is people really need to be under the care of a health care provider who understands CBD. They need to be monitored and managed by that individual, and not just go out and buy CBD thinking it’s going to be the answer,” Welty said.

Show Sources

SOURCES: Marcel Bonn-Miller, Ph.D., adjunct assistant professor, psychology in psychiatry, University of Pennsylvania School of Medicine, Philadelphia; Timothy Welty, Pharm.D., chair, department of clinical sciences, College of Pharmacy and Health Sciences, Drake University, Des Moines, Iowa

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