CBD Oil And Liver Disease In Dogs


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CBD is a powerful therapy for dogs suffering with liver disease from cancer, infection, toxins, poor diet, and more. But there is some reason for caution. What a Dog's Liver Does Where is A Dog's Liver Located Liver Problems in Dogs What is Liver Damage in Dogs? What is Liver Disease and Chronic Liver Disease in Dogs? What Causes Canine Liver Disease and Damage? What is Liver Failure? Stages of Liver Failure in Dogs How to Know Your Dog has Liver Damage or Liver Disease?

How Can CBD Help Treat Liver Issues in Dogs?

The rising popularity of CBD products for dogs has inspired many pet owners to get on board with giving the supplement to their companion animals for a wide variety of conditions. These include epilepsy and seizures, cancer, pain, inflammation, joint and bone health, diabetes, and arthritis. CBD also serves as an immune system regulator, a neuro-protector, antibacterial and post surgical assistant to healing. As such, it is becoming a prized remedy for supporting pet health.

Studies on the benefits of CBD for dogs are few and are just beginning to appear in larger numbers. These studies have focused primarily on the use of CBD for treating arthritis and epilepsy in dogs, as well as for canine pain relief. There is a group of disorders, however, for which CBD may be or great benefit for dogs, and that is the category of liver disease. There are no long-term studies on the efficacy of CBD for treating these conditions, but many holistic vets feel it has an important role to play in this area.

Types of Liver Disease in Dogs

The liver is the second largest organ in a dog’s body, the largest being the skin. It plays a critical part in metabolism and breaking down toxins, in all being responsible for some 1,500 different biological processes. The liver filters the blood, produces bile to break down fats, produces proteins that are responsible for clotting, regulates blood levels of amino acids, stores iron that is used in the processing of hemoglobin, helps the animal to resist infections by filtering bacteria from the bloodstream, and much more. When the liver is compromised, the result can be a variety of serious health issues for the dog.

The primary challenges to canine liver health are:

2. Toxic plants and chemicals

4. Cancer and tumors

7. Congenital conditions

Let’s look at each of these individually.


Fungi, parasites, viruses (such as Adenovirus)and bacterial infections (such as Leptospirosis) can invade a dog’s body, infect the liver, and cause extensive damage. Leptospirosis — one of the most common infections — is spread to dogs via contact with wildlife such as rodents that carry the bacteria. The Leptospirosis spirochetes invade the body, spreading to and reproducing in the liver, kidneys, eyes, central nervous system, and reproductive system. The most obvious indication of this condition is fever, which often resolves upon the development of antibodies produced by the animal’s immune system. However, if the immune system is compromised, it is difficult for the dog’s body to resist the infection and the result can be fatal.

Toxic Plants and Chemicals

The liver is the first line of defense against environmental toxins. These toxins are ubiquitous in the homes and gardens of pet owners in the form of common plants that are toxic to dogs. These include aloe, begonia, daffodil, castor bean, sago palm, autumn crocus, lilies, tomato leaves, and many others. Foods such as raisins or chocolate are well-known canine hazards. And exposure to household cleaning products and a variety of other chemicals can cause poisoning and liver damage.


Drugs, even those prescribed by veterinarians, can be harmful to dogs. Pharmaceuticals account for much of the poor health seen in animals treated via conventional medical means. Prednisone, phenobarbital, and tetracycline are among the commonly administered medications that can cause canine hepatic disease.

Cancer and tumors

Liver cancer in dogs can be caused by exposure to pesticides, herbicides, or other environmental chemicals. It can also be the result of molds found in common pet food additives, diabetes, long-term use of painkillers, parasites, and untreated heartworms, among other causes. The cancer may spread to other vital organs if not treated.


Commercial pet food is often contaminated with aflatoxins, which are a major contributor to poor health in companion animals. Aflatoxins are a type of mycotoxin that come from the Aspergillus fungus and can not be killed by high temperatures, so even cooked foods are likely to contain them. They are found in foods such as corn, wheat, soybeans, peanuts, Brazil nuts, rice and walnuts. Aflatoxins bind with DNA and cause cell mutations which lead to cancer. Low cost kibble is most likely to contain these substances, but even premium quality brands have been found to harbor aflatoxins. Chronic exposure to aflatoxins has been associated with increased risk of liver cancer (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314947/).


Vaccination has an important role to play in maintaining a dog’s health. However, there are risks associated with over-vaccination. Finding the proper balance between core vaccines (those that all dogs should receive to be protected against serious diseases such as distemper, adenovirus, parovirus, and rabies) and non-core vaccines (those given based on individual need). Vaccination schedules should depend on lifestyle and exposure factors, and is ultimately a decision to be made by the individual pet owner in consultation with their veterinarian. Many holistic vets feel that over-vaccination can lead to chronic illness in pets, including certain types of cancer originating from vaccination-caused inflammation.

Congenital Conditions

A congenital liver shunt is an abnormal but common condition in dogs. A shunt results from a birth defect known as PSS or portosystemic shunt. It is an abnormal blood vessel that connects the digestive tract with the circulatory system, bypassing the liver and preventing it from filtering proteins that need to be digested and absorbed in the gut. As a result, proteins are diverted into the bloodstream instead of being processed through the liver. This condition results in a variety of health problems including poor growth, low appetite, weight loss, vomiting, diarrhea and neurological problems.

How Can CBD Help Treat Liver Issues in Dogs?

CBD has an important role to play in healing liver disease. It can be part of a targeted treatment approach that includes diet, nutritional supplements, veterinary supervision and pharmaceuticals if indicated. Here are a few primary ways that CBD can help dogs being treated for liver conditions.

· Inhibits tumor growth

· No harmful side effects

· Decreases side effects of conventional cancer treatments

· Reduces pain and inflammation

· Maintains healthy appetite

· Treats symptoms such as nausea, vomiting, diarrhea, vertigo, thus making dog more comfortable and improving quality of life.

When Should CBD Not Be Used for Canine Liver Disease?

There are two areas in which using CBD to treat liver disease comes with caveats. One is congenital liver shunts. Dr. Michael Dym, DVM (http://doctordym.com) says that when treating these conditions his focus is on cutting down on the workload for the liver. This includes switching to a high quality low protein diet and using supplements such as SAMe and milk thistle, rather than using CBD. He’s hesitant about using supplements with all liver conditions, but particularly with congenital issues. “We don’t really know the effects,” he says. He has no hesitation, however, about using CBD for cancer, toxicity, infection, and problems caused by diet and over-vaccination.

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The other time to be cautious is when an animal is on pharmaceuticals. Cytochrome P450 is a family of enzymes that play a key role in the metabolism of medications, including both veterinary drugs and CBD. As a consequence, they could interfere with one another’s effectiveness. Dr. Dym says that “they don’t actually neutralize each other, but [given] the fact that [both] are metabolized with the liver Cytochrome P450 system, we just have to be mindful when the liver is chronically compromised.” He may use slightly lower doses of CBD in these cases while being careful to support the liver with appropriate diet and nutrition and closelymonitor the dog..

The Big Picture: CBD as a Treatment Option For Your Dog

CBD offers enormous potential benefits for dogs with liver conditions and should not be overlooked as a treatment option. A good holistically oriented vet will use a comprehensive approach including dietary and nutritional support while conducting regular lab tests to track the animal’s progress.

A reputable holistic vet will also take great care to select high-quality CBD brands — carefully sourced, organically grown, and rigorously tested — to use in their practice. Choose a good vet who does their research, and the rest of the picture will be easier to sort out. And a good prognosis for your pup will be the most likely result.

Important Facts About Liver Disease in Dogs

Liver problems are a pretty common issue for dogs, so it is wise as a dog owner to understand what to look for and how to keep your dog’s liver function healthy. Sometimes it is even necessary to take proactive measures to protect some dogs’ livers. This post will explain everything about liver disease in dogs, including how CBD Oil can help.

What a Dog’s Liver Does

While not spoken about much, the liver is the largest organ of a dog’s body after their skin and it is incredibly important in helping their body function normally. It performs more than 1,000 crucial bodily functions impacting the blood clotting, nutrient management, toxin elimination, hormones, metabolism, and more.

Poor liver health is also much more common than most dog owners realize. Liver disease in dogs is one of the top five causes of non-accidental death in dogs of any age and one of the top four causes of death in older dogs.

Where is A Dog’s Liver Located

It’s natural to wonder this when thinking about the liver and potential problems with it. A dog’s liver is located in the center of the abdomen between their lungs and stomach. Kind of like the center of the dog’s belly, working toward the front half of the dog.

Liver Problems in Dogs

There are many liver disorders that can go wrong with a dog; acute liver failure, infectious canine hepatitis, endocrine diseases, liver cancer and many more. Most occur later in the dog’s life, but some can occur at any time and some occur at birth.

In this post, we’ll discuss most of the causes as well as the symptoms and treatment options for them.

What is Liver Damage in Dogs?

The liver becomes damaged before it becomes diseased, similar to how gingivitis left untreated becomes periodontal disease.

The problem is that liver damage has vague symptoms and an underlying cause that doesn’t seem obviously connected to the liver. Blood tests and testing liver tissue are needed for a definitive diagnosis of the most common liver disorders.

Symptoms of liver damage in dogs include:
  • loss of appetite
  • diarrhea
  • unexplained weight loss
  • darker urine
  • poor coat quality
  • hair loss
  • brittle, weakened, or infected nails
  • weakness
  • fatigue
  • irritability and/or aggression
  • generally seeming unwell

As you can see, most pet parents would get concerned about their dog when displaying these symptoms, but we probably wouldn’t think about their liver unless we knew to do so.

It is very important to be aware of this potential because catching liver damage before liver failure occurs in dogs makes a tremendous difference in the chances of recovery.

Investigate these symptoms to determine their cause, and be proactive about your dog’s liver health before they show these symptoms or as soon as you notice the symptoms.

What is Liver Disease and Chronic Liver Disease in Dogs?

Liver disease in dogs can be an acute disease brought on by poisoning or a chronic disease brought on by a vast array of factors like copper storage or another kidney disease like diabetes. No matter the cause, they all mean the same thing, the dog’s liver function is unwell.

The reason for the liver disease does impact how quickly the symptoms appear, so do not rule out liver disease in dogs because symptoms are either sudden or gradual. Both situations can happen with liver disease, depending on its cause.

Chronic Liver Disease in Dogs is not the same as Chronic Liver Failure. It’s a chronic, progressive disease that can lead to complete failure of the liver and death if left untreated or improperly managed.

What are some signs of Chronic Liver Disease?

Some symptoms may be yellowing eyes, vomiting bile acids-stained vomit, abdominal pain caused by enlarged livers pressing on other organs such as kidneys or intestines; occasionally bloating due to fluid accumulation secondary to hepatomegaly (enlarged liver).

Symptoms of liver disease in dogs include:
  • jaundice, yellowing of skin, gums, and eyes
  • vomiting
  • blood in pee
  • blood in poop
  • increased urination
  • increased thirst
  • fluid retention and swelling in the abdomen
  • lack of coordination
  • confusion
  • blindness

It is imperative to have liver disease diagnosed as quickly as possible. The disease ravages the body, damaging other bodily functions even up until 80% of the liver is damaged. This means your dog still maintains some appearance of health while the disease is growing ever more difficult to treat, eventually impossibly to do so. Do not wait until your dog appears seriously ill to have them checked for liver disease.

What Causes Canine Liver Disease and Damage?

There are many causes of liver damage and disease. Below we have listed and discussed some of the main factors in liver diseases.

Getting Older

Dogs are more likely to develop liver damage as they age. Like any other organ, it both starts to function less optimally over time and has had time to suffer from damaging things that have happened to it.


Prescribed medications can cause liver damage because they have to be processed by the liver. Medications contain chemicals that the dog’s liver must filter out like it does toxins, if the amount that passes through is larger than the dog’s liver can handle, it can cause damage and disease. This should not be a problem unless the dog is taking a very large dose of medication, has been placed on a medication for a very long time, or there is already something wrong with the dog’s liver, and your vet should discuss risks versus benefits for either of these situations.

Medications containing the most chemicals that may eventually damage the liver are flea and tick, deworming, vaccinations, and painkilling medications.


Lead, iron, salt, copper, mercury, phosphorus, cleaning supplies, poisons, insect bites and stings, mold, toxic foods, and toxic plants can lead to acute or chronic liver damage depending on the quantities ingested and the number of ingestions. Genetically predisposed dogs will be more at risk with these factors so pet owners should always be aware of their breeds genetic make up if possible.

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Copper Storage

If the dog’s body retains too much copper, it will collect in the liver and cause damage and eventually disease. Some breeds like German Shepherds, Golden Retrievers, Labrador Retrievers, Poodles, and Yorkshire Terriers have an increased likelihood of developing copper storage disease.

Fatty Liver Disease

Toy breeds and small breed dogs are prone to developing fatty liver disease where triglycerides build up in the dog’s liver and lead to damage and disease. IT’s a good idea to monitor your dog’s diet in this situation.


There are some genes that do not breed-specific that cause a blood flow issue impacting the liver and leading to damage and disease.

Other Diseases

A dog with diabetes, heartworms, heart disease, pancreatic diseases, or viral and a bacterial infection can develop a damaged and diseased liver. It is important to be on the alert for liver issues, have routine checkups, and be proactive regarding liver health if you have a dog with any of these conditions or diseases.

What is Liver Failure?

If liver disease progresses far enough, it will become irreversibly fatal. At this point, it becomes a matter of quality of life. Liver failure can also come on quickly, such as after a dog ingests a sizeable amount of poison.

Symptoms of liver failure are the same as the ones for liver disease, but they are more pronounced. The dog may end up in a coma at this point.

Stages of Liver Failure in Dogs

Licensed veterinarians grade liver failure in stages, similar to how they do cancer.

The first stage is liver damage and it involves inflammation. The liver is being attacked and is trying to heal itself.

The second stage of liver disease occurs when inflammation has persisted long enough to cause the liver to harden and develop scars. This can be reversible if treatment is begun soon enough.

The third stage of liver disease involves permanent scarring. Treatment at this time consists of trying to preserve the health of the rest of the liver.

The fourth stage is liver failure and this is pretty much end stage liver disease. The liver no longer functions as it should and cannot be healed enough to maintain the health of the dog. Treatments involve maintaining comfort and quality of life for as long as possible.

How to Know Your Dog has Liver Damage or Liver Disease?

Diagnosis of liver disease consists of several potential steps.

The licensed veterinarian will observe the dog, looking for a distended abdomen, gastrointestinal signs, neurologic signs, jaundice, issues with the skin or coat, pale mucous membranes, signs of dehydration, lack of coordination, weight loss and lethargy.

If these symptoms and indications are present, they will move on to a blood test, a complete blood count, then test their bile and urine, and afterwards a biopsy may be needed.

Imaging may be needed to determine if any scarring is present.

How to Treat Liver Damage and Liver Disease

Prevention is the best treatment if you still have the opportunity.

Limit the dog’s exposure to chemicals and toxins like toxic foods and plants, cleaning products, pesticides, etc.

Avoid fatty foods and foods containing toxins, like some human foods.

Educate yourself on vaccinations and medications that are prescribed for your dog. Ensure that your vet is not overprescribing either and is taking into account the risks versus the benefits of the medication. Medications can be a life-saver for your dog, but they can also make them sick, so do not automatically assume all medications are good or bad for your dog. To protect your dog by double-checking the information and weighing out the situation yourself.

Take your dog to yearly checkups. This is particularly important for dogs that are more likely to develop liver disease.

Once liver damage or liver disease has been discovered, treatment may consist of:
  • fluids, electrolytes, and oxygen for acute liver disease
  • liver medications
  • SAM-E or milk thistle
  • changing diet to one higher in vitamins and minerals
  • rest
  • treatment of another condition causing the liver damage

CBD Oil for Canine Liver Disease and Liver Failure

CBD oil could help manage liver damage, and studies show it can also improve the symptoms associated with liver disease and liver failure.

CBD is cannabidiol, a hemp-derived cannabinoid that helps a dog’s body regulate its own cannabinoids. Yes, scientists have discovered that humans and dogs have an endocannabinoid system, cannabinoid receptors all over the body, that play a huge part in managing health and wellness. External cannabinoids like cannabidiol jump start the body’s ability to do what it is already supposed to be doing but may be struggling at.

The many benefits of CBD is dazzling scientists with its ability to impact a broad spectrum of health aspects, some of which may be a huge benefit to your dog with liver disease or an increased risk of developing liver disease.

CBD oil studies show that it is a powerful anti-inflammatory and since inflammation is what damages the liver, you can see how using CBD oil could be beneficial to managing liver damage and its symptoms.

CBD may also:
  • alleviate pain
  • improve mood
  • reduce stress
  • boost energy
  • soothe digestive issues
  • provide nutrients
  • help dogs sleep with higher doses
  • prevent and lessen seizures
  • improve balance

While undergoing treatments for liver disease, or dealing with a failed liver, CBD can improve the dog’s life, easing symptoms that make treatments less effective and making them feel better.

Are there downsides to using CBD oil for liver failure in dogs?

CBD comes from the cannabis family, and it may share many health benefits with marijuana, but it does not contain THC, so you don’t have to worry about your dog being “high.” Minimal, if any.

CBD is not a healthy hammer, whopping a dog’s body with feel good benefits and then leaving them to crash. It manages and regulates functions that help the dog’s body maintain its own health.

There are virtually no side effects. If the dog takes a very large dose of CBD, they may experience diarrhea, changes in appetite, or sedation. That’s a far safer sounding list of side effects than most prescription medications can offer.

CBD is not tried and true like traditional medications. The science is still new regarding it, and while it does show great promise and even veterinarians consider it a worthy secondary or primary treatment in many cases, you don’t want to rule out the possibility that another route may prove necessary. CBD is best used when other treatments are proven ineffective, the side effects of traditional treatment are threatening its success, or a disease has gone too far to be treated with conventional means.

Using CBD Oil

There are several types of CBD oil you can purchase for your dog with liver disease:
  • oil tinctures
  • extract concentrates
  • capsules
  • treats

CBD Oil tinctures come with a dropper or sprayer so the oil can be applied directly to the dog’s mouth or to their food. It is often flavored to mask the distinctive and often off-putting taste of hemp.

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CBD Capsules avoid the whole taste issue and can be easier to get into some dogs. They should contain only CBD oil and what ingredients are necessary to turn it into a capsule. CBD Extract concentrates contain nothing but CBD oil and can be applied to the dog’s mouth or their food. These are the most cost-effective option and guaranteed to be free of any weird ingredients, but they may be harder to get into a dog because of the taste.

Hemp Dog Treats are the easiest delivery method for CBD as treats are fun. You can add these to your pet’s diet or replace a current treat with them. Check the ingredients list for fat, copper, or any other substance a dog shouldn’t have for liver concerns. They shouldn’t be in there, but it’s wise to look.

Dosing CBD for pets instructions come on the package of the CBD product and will be based on the dog’s size. Very small, large, young, old, or sick dogs may have special dosing requirements. It is wise to consult your veterinarian to discuss CBD use so they can help you determine the exact dosages for your individual dog and so they’ll know the dog is taking CBD should it impact their treatments.

Purchasing CBD Oil

There are certain things you should look for when purchasing CBD oil.

Full-spectrum versus CBD isolate

Both of these types of CBD are quite good, but you should know which one you are buying because some people find that one works better than the other for their unique situation and you need to know which ones do work for your dog so you can buy it again.

CBD isolate is just CBD, while full-spectrum is CBD with other cannabinoids, terpenes, and nutrients found in the hemp plant. Full-spectrum is actually the most popular option and may be the best one to choose for your dog with liver disease as it also contains additional nutrients. Should full-spectrum let you down, don’t give up on CBD altogether. You may find that CBD isolate works for your dog.

Third-party Testing

Tragically, all CBD products are not legitimate. Some manufacturers sell CBD products that do not contain enough CBD or any CBD at all! This is why reputable CBD manufacturers supply their third-party lab test results to prove they are offering what they say they’re offering.

Extraction Method

Choose manufacturers who say they used the CO2 extraction method as this is the safest and purest one.


Look for CBD products with only necessary, safe, and natural ingredients. Organic is best. As mentioned in the treat section, take special precautions to check for ingredients that may be harmful to the liver.

Innovations from Innovet

Innovet started out making CBD products to help dogs manage hard-to-treat ailments, and we know that means unique challenges. If your dog has a specific need not met by current CBD products, please contact us so we can try to find a solution for your dog.


Doctor of Veterinary Medicine, St. Georges University

Sara Redding Ochoa, DVM was raised in north Louisiana. She graduated from LA Tech in 2011 with a degree in animal science. She then moved to Grenada West Indies for veterinary school. She completed her clinical year at Louisiana State University and graduated in 2015 from St. George’s University. Since veterinary school, she has been working at a small animal and exotic veterinary clinic in east Texas, where she has experience treating all species that walk in the hospital. In her free time, she likes to travel with her husband Greg, bake yummy desserts and spend time with her 4-legged fur kids, a dog Ruby, a cat Oliver James “OJ”, a rabbit BamBam and a tortoise MonkeyMan.

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The Innovet Team

Please do not ask for emergency or specific medical questions about your pets in the comments . Innovet Pet Products is unable to provide you with specific medical advice or counseling. A detailed physical exam, patient history, and an established veterinarian are required to provide specific medical advice. If you are worried that your pet requires emergency attention or if you have specific medical questions related to your pet’s current or chronic health conditions, please contact or visit your local/preferred veterinarian, an animal-specific poison control hotline, or your local emergency veterinary care center.

Please share your experiences and stories, your opinions and feedback about this blog, or what you’ve learned that you’d like to share with others.

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Due to liability issues, we can not provide advice when it comes to medications or prescriptions. Our customers use our product for many different things along with other medications. So many that, it is hard for us to keep track of. We created a Facebook group for our customers to discuss what they use our product for, what works and what doesn’t, etc. It is called Innovet Pet Talk & Support: CBD for Dogs, Cats, & More. Perhaps you can find more information there

For additional help in managing your pet’s specific medical condition – whether with CBD or not – we advise you to consult only with a licensed veterinarian for medical advice.

My Yorkie name is Bailey and he has a liver problem and he takes medication for it, and it’s really costing me a lot of money to keep him healthy and Happy, his weight is 8.96 pounds and he takes the medication called DENAMARIN, it costs me $32.00 Dollars each month and I am afraid that I can’t keep on helping with his medication, it’s so expensive. Please tell me what I should do. PLEASE.

**Review Disclaimer: In accordance with FDA/FTC regulations regarding product/advertising claims and to ensure full transparency to the public testimonials displayed on innovetpet.com are given verbatim as we do not have the ability to change any reviews made by customers. Testimonials appearing on this site are actually received online and are processed through YOTPO – the leading independent review auditor. These are individual experiences of real-life people who have administered our products to their pets. However, they are individual results and results do vary. The testimonials are not necessarily representative of all of those who will use our products and/or services. Innovetpet.com is not a forum for testimonials, however, we do provide testimonials as a means for customers to share their experiences with each other. Innovet Pet does not necessarily share the opinions, views, or commentary of any testimonials on this site specifically because such views are strictly the views of the reviewer.
Additionally, these testimonials are not intended to make or imply claims that these products can be used to diagnose, treat, cure, mitigate, or prevent any disease. Statements within these testimonials have not been clinically reviewed or evaluated by the FDA. Please consult your veterinarian about potential interactions or other possible complications before using any product. The information on our website is intended to inform the public in the most honest and transparent way possible.

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