Bishop’s Weed Seed

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Bishop’s Weed Ajava Seeds, Ajowan, Ajowan Caraway, Ajowan Seed, Ajowanj, Ajwain, Ajwan, Ameo Bastardo, Ammi Commun, Ammi Élevé, Ammi glaucifolium, Ammi Inodore, Ammi majus, Ammi Officinal, Learn more about BISHOP’S WEED uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain BISHOP’S WEED. Bishop's weed (Aegopodium podagraria) is ideal in contained and shady spots as a fast-growing ground cover. It can be aggressive though.

Bishop’s Weed

Ajava Seeds, Ajowan, Ajowan Caraway, Ajowan Seed, Ajowanj, Ajwain, Ajwan, Ameo Bastardo, Ammi Commun, Ammi Élevé, Ammi glaucifolium, Ammi Inodore, Ammi majus, Ammi Officinal, Bishop’s Flower, Bisnague, Bullwort, Carum, Espuma del Mar, Flowering Ammi, Grand Ammi, Omum, Yavani.

Overview

Bishop’s weed is a plant. The seeds are used to make medicine.

The prescription drug methoxsalen (Oxsoralen, Methoxypsoralen) was originally prepared from bishop’s weed, but it is now made in the laboratory. Methoxsalen is used to treat psoriasis, a skin condition.

Bishop’s weed is used for digestive disorders, asthma, chest pain (angina), kidney stones, and fluid retention.

Some people apply bishop’s weed directly to the skin for skin conditions including psoriasis and vitiligo.

Be careful not to confuse bishop’s weed (Ammi majus) with its more commonly used relative, khella (Ammi visnaga). The two species do contain some of the same chemicals and have some similar effects in the body. But Bishop’s weed is more commonly used for skin conditions, and khella is usually used for heart and lung conditions.

How does it work?

Bishop’s weed contains several chemicals, including methoxsalen, a chemical used to make a prescription medication for the skin condition psoriasis.

SLIDESHOW

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for.
  • Skin conditions such as psoriasis and vitiligo.
  • Digestive problems.
  • Asthma.
  • Chest pain.
  • Kidney stones.
  • Fluid retention.
  • Other conditions.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

There isn’t enough information to know if bishop’s weed is safe. When taken by mouth, bishop’s weed might cause nausea, vomiting, and headache. Some people are allergic to bishop’s weed. They can get a runny nose, rash, or hives. There is also some concern that bishop’s weed might harm the liver or the retina of the eye.

Bishop’s weed can cause skin to become extra sensitive to the sun. This might put you at greater risk for skin cancer. Wear sunblock outside, especially if you are light-skinned.

QUESTION

Special Precautions & Warnings

Pregnancy and breast-feeding: It’s UNSAFE to use bishop’s weed if you are pregnant. It contains a chemical called khellin that can cause the uterus to contract, and this might threaten the pregnancy.

It’s also best to avoid using bishop’s weed if you are breast-feeding. There isn’t enough information to know whether it is safe for a nursing infant.

Liver disease: There is some evidence that bishop’s weed might make liver disease worse.

Surgery: Bishop’s weed might slow blood clotting. There is a concern that it might increase the risk of bleeding during and after surgery. Stop using bishop’s weed at least 2 weeks before a scheduled surgery.

Interactions

Medications changed by the liver (Cytochrome P450 3A4 [CYP3A4] substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver. Bishop’s weed might decrease how quickly the liver breaks down some medications. Taking bishop’s weed along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking bishop’s weed, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

Medications that can harm the liver (Hepatotoxic drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Bishop’s weed might harm the liver. Taking bishop’s weed along with medication that might also harm the liver can increase the risk of liver damage. Do not take bishop’s weed if you are taking a medication that can harm the liver.

Some medications that can harm the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others.

Medications that increase sensitivity to sunlight (Photosensitizing drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications can increase sensitivity to sunlight. Bishop’s weed might also increase your sensitivity to sunlight. Taking bishop’s weed along with medication that increases sensitivity to sunlight could increase the chances of sunburn, blistering, or rashes on areas of skin exposed to sunlight. Be sure to wear sunblock and protective clothing when spending time in the sun.

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Some drugs that cause photosensitivity include amitriptyline (Elavil), Ciprofloxacin (Cipro), norfloxacin (Noroxin), lomefloxacin (Maxaquin), ofloxacin (Floxin), levofloxacin (Levaquin), sparfloxacin (Zagam), gatifloxacin (Tequin), moxifloxacin (Avelox), trimethoprim/sulfamethoxazole (Septra), tetracycline, methoxsalen (8-methoxypsoralen, 8-MOP, Oxsoralen), and Trioxsalen (Trisoralen).

Medications that slow blood clotting (Anticoagulant/Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Bishop’s weed might slow blood clotting. Taking bishop’s weed along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Dosing

The appropriate dose of bishop’s weed depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for bishop’s weed. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Health Solutions From Our Sponsors

Dollahite, J. W., Younger, R. L., and Hoffman, G. O. Photosensitization in cattle and sheep caused by feeding Ammi majus (greater Ammi; Bishop’s-Weed). Am J Vet.Res 1978;39(1):193-197. View abstract.

EL MOFTY, A. M. Observations on the use of Ammi majus Linn. In vitiligo. Br J Dermatol 1952;64(12):431-441. View abstract.

EL MOFTY, A. M., el Sawalhy, H., and el Mofty, M. Clinical study of a new preparation of 8-methoxypsoralen in photochemotherapy. Int J Dermatol 1994;33(8):588-592. View abstract.

Kavli, G. and Volden, G. Phytophotodermatitis. Photodermatol. 1984;1(2):65-75. View abstract.

Singh, U. P., Singh, D. P., Maurya, S., Maheshwari, R., Singh, M., Dubey, R. S., and Singh, R. B. Investigation on the phenolics of some spices having pharmacotherapeuthic properties. J Herb.Pharmacother. 2004;4(4):27-42. View abstract.

Abdel-Fattah A, Aboul-Enein MN, Wassel GM, El-Menshawi BS. An approach to the treatment of vitiligo by khellin. Dermatologica 1982;165:136-40. View abstract.

Ahsan SK, Tariq M, Ageel AM, et al. Effect of Trigonella foenum-graecum and Ammi majus on calcium oxalate urolithiasis in rats. J Ethnopharmacol 1989;26:249-54. View abstract.

Bethea D, Fullmer B, Syed S, et al. Psoralen photobiology and photochemotherapy: 50 years of science and medicine. J Dermatol Sci 1999;19:78-88. View abstract.

Bourinbaiar AS, Tan X, Nagorny R. Inhibitory effect of coumarins on HIV-1 replication and cell-mediated or cell-free viral transmission. Acta Virol 1993;37:241-50.

Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.

Dr. Duke’s Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.

Fetrow CW, Avila JR. Professional’s Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.

Hamerski D, Schmitt D, Matern U. Induction of two prenyltransferases for the accumulation of coumarin phytoalexins in elicitor-treated Ammi majus cell suspension cultures. Phytochemistry 1990;29:1131-5. View abstract.

Harvengt C, Desager JP. HDL-cholesterol increase in normolipaemic subjects on khellin: a pilot study. Int J Clin Pharmacol Res 1983;3:363-6. View abstract.

Kiistala R, Makinen-Kiljunen S, Heikkinen K, et al. Occupational allergic rhinitis and contact urticaria caused by bishop’s weed (Ammi majus). Allergy 1999;54:635-9. View abstract.

Malhotra S, Bailey DG, Paine MF, Watkins PB. Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins. Clin Pharmacol Ther 2001;69:14-23. View abstract.

Osher HL, Katz KH, Wagner DJ. Khellin in the treatment of angina pectoris. N Engl J Med 1951;244:315-21. View abstract.

Ossenkoppele PM, van der Sluis WG, van Vloten WA. [Phototoxic dermatitis following the use of Ammi majus fruit for vitiligo]. Ned Tijdschr Geneeskd 1991;135:478-80. View abstract.

Shlosberg A, Egyed MN. Examples of poisonous plants in Israel of importance to animals and man. Arch Toxicol Suppl 1983;6:194-6. . View abstract.

Tritrungtasna O, Jerasutus S, Suvanprakorn P. Treatment of alopecia areata with khellin and UVA. Int J Dermatol 1993;32:690. View abstract.

BISHOP’S WEED – Uses, Side Effects, and More

Bishop’s weed is a flowering plant. The seeds are used to make medicine.

Bishop’s weed is used for asthma, chest pain (angina), kidney stones, a skin disorder that causes white patches to develop on the skin (vitiligo), and scaly, itchy skin (psoriasis), but there is no good scientific evidence to support these uses.

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Be careful not to confuse bishop’s weed (Ammi majus) with its more commonly used relative, khella (Ammi visnaga).

How does it work ?

Bishop’s weed contains several chemicals that can make the skin more sensitive to sunlight.

Uses & Effectiveness ?

Insufficient Evidence for

  • Asthma.
  • Chest pain (angina).
  • Kidney stones.
  • Fluid retention.
  • Scaly, itchy skin (psoriasis).
  • White patches to develop on the skin (vitiligo).
  • Other conditions.

Side Effects

When taken by mouth: There isn’t enough reliable information to know if bishop’s weed is safe. It might cause nausea, vomiting, and headache. Some people are allergic to bishop’s weed.

When applied to the skin: There isn’t enough reliable information to know if bishop’s weed is safe. It may cause the skin to become extra sensitive to the sun. This might put you at greater risk for skin cancer. Wear sunblock outside, especially if you are light-skinned.

Special Precautions and Warnings

When taken by mouth: There isn’t enough reliable information to know if bishop’s weed is safe. It might cause nausea, vomiting, and headache. Some people are allergic to bishop’s weed.

When applied to the skin: There isn’t enough reliable information to know if bishop’s weed is safe. It may cause the skin to become extra sensitive to the sun. This might put you at greater risk for skin cancer. Wear sunblock outside, especially if you are light-skinned. Pregnancy: It’s LIKELY UNSAFE to use bishop’s weed if you are pregnant. It contains a chemical called khellin that can cause the uterus to contract. This might threaten the pregnancy.

Breast-feeding: There isn’t enough reliable information to know if bishop’s weed is safe to use when breast-feeding. Stay on the safe side and avoid use.

Surgery: Bishop’s weed might slow blood clotting. There is a concern that it might increase the risk of bleeding during and after surgery. Stop using bishop’s weed at least 2 weeks before a scheduled surgery.

Interactions ?

Moderate Interaction

Be cautious with this combination

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with BISHOP’S WEED

Some medications are changed and broken down by the liver. Bishop’s weed might decrease how quickly the liver breaks down some medications. Taking bishop’s weed along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking bishop’s weed, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

Medications that increase sensitivity to sunlight (Photosensitizing drugs) interacts with BISHOP’S WEED

Some medications can increase sensitivity to sunlight. Bishop’s weed might also increase your sensitivity to sunlight. Taking bishop’s weed along with medication that increases sensitivity to sunlight could increase the chances of sunburn, blistering, or rashes on areas of skin exposed to sunlight. Be sure to wear sunblock and protective clothing when spending time in the sun.

Some drugs that cause photosensitivity include amitriptyline (Elavil), Ciprofloxacin (Cipro), norfloxacin (Noroxin), lomefloxacin (Maxaquin), ofloxacin (Floxin), levofloxacin (Levaquin), sparfloxacin (Zagam), gatifloxacin (Tequin), moxifloxacin (Avelox), trimethoprim/sulfamethoxazole (Septra), tetracycline, methoxsalen (8-methoxypsoralen, 8-MOP, Oxsoralen), and Trioxsalen (Trisoralen).

Medications that slow blood clotting (Anticoagulant/Antiplatelet drugs) interacts with BISHOP’S WEED

Bishop’s weed might slow blood clotting. Taking bishop’s weed along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Dosing

The appropriate dose of bishop’s weed depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for bishop’s weed. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Dollahite, J. W., Younger, R. L., and Hoffman, G. O. Photosensitization in cattle and sheep caused by feeding Ammi majus (greater Ammi; Bishop’s-Weed). Am J Vet.Res 1978;39(1):193-197. View abstract.

EL MOFTY, A. M. Observations on the use of Ammi majus Linn. In vitiligo. Br J Dermatol 1952;64(12):431-441. View abstract.

EL MOFTY, A. M., el Sawalhy, H., and el Mofty, M. Clinical study of a new preparation of 8-methoxypsoralen in photochemotherapy. Int J Dermatol 1994;33(8):588-592. View abstract.

Kavli, G. and Volden, G. Phytophotodermatitis. Photodermatol. 1984;1(2):65-75. View abstract.

Singh, U. P., Singh, D. P., Maurya, S., Maheshwari, R., Singh, M., Dubey, R. S., and Singh, R. B. Investigation on the phenolics of some spices having pharmacotherapeuthic properties. J Herb.Pharmacother. 2004;4(4):27-42. View abstract.

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Abdel-Fattah A, Aboul-Enein MN, Wassel GM, El-Menshawi BS. An approach to the treatment of vitiligo by khellin. Dermatologica 1982;165:136-40. View abstract.

Ahsan SK, Tariq M, Ageel AM, et al. Effect of Trigonella foenum-graecum and Ammi majus on calcium oxalate urolithiasis in rats. J Ethnopharmacol 1989;26:249-54. View abstract.

Bethea D, Fullmer B, Syed S, et al. Psoralen photobiology and photochemotherapy: 50 years of science and medicine. J Dermatol Sci 1999;19:78-88. View abstract.

Bourinbaiar AS, Tan X, Nagorny R. Inhibitory effect of coumarins on HIV-1 replication and cell-mediated or cell-free viral transmission. Acta Virol 1993;37:241-50.

Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.

Dr. Duke’s Phytochemical and Ethnobotanical Databases. Available at: https://www.ars-grin.gov/duke/.

Fetrow CW, Avila JR. Professional’s Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.

Hamerski D, Schmitt D, Matern U. Induction of two prenyltransferases for the accumulation of coumarin phytoalexins in elicitor-treated Ammi majus cell suspension cultures. Phytochemistry 1990;29:1131-5. View abstract.

Harvengt C, Desager JP. HDL-cholesterol increase in normolipaemic subjects on khellin: a pilot study. Int J Clin Pharmacol Res 1983;3:363-6. View abstract.

Kiistala R, Makinen-Kiljunen S, Heikkinen K, et al. Occupational allergic rhinitis and contact urticaria caused by bishop’s weed (Ammi majus). Allergy 1999;54:635-9. View abstract.

Malhotra S, Bailey DG, Paine MF, Watkins PB. Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins. Clin Pharmacol Ther 2001;69:14-23. View abstract.

Osher HL, Katz KH, Wagner DJ. Khellin in the treatment of angina pectoris. N Engl J Med 1951;244:315-21. View abstract.

Ossenkoppele PM, van der Sluis WG, van Vloten WA. [Phototoxic dermatitis following the use of Ammi majus fruit for vitiligo]. Ned Tijdschr Geneeskd 1991;135:478-80. View abstract.

Shlosberg A, Egyed MN. Examples of poisonous plants in Israel of importance to animals and man. Arch Toxicol Suppl 1983;6:194-6. . View abstract.

Tritrungtasna O, Jerasutus S, Suvanprakorn P. Treatment of alopecia areata with khellin and UVA. Int J Dermatol 1993;32:690. View abstract.

How to Grow Goutweed

A fast-growing ground cover that can easily get out of control

Gemma Johnstone is a gardening expert who has written 120-plus articles for The Spruce covering how to care for a large variety of plants from all over the world. She’s traveled all over Europe, living now in Italy.

The Spruce / K. Dave

Several plant species are referred to as goutweed. The most popular is Aegopodium podagraria. This is a herbaceous perennial that works well as a shrubby, semi-wild ground cover option. It’s fast-growing, hardy, and low-maintenance.

The leafy, spreading foliage normally doesn’t grow much taller than 10 inches, but the flowering stalks that appear in early summer can shoot up much taller. Its small, white flower umbels aren’t particularly ornamental, and some people simply cut the flowering stalks back to prevent the ground cover from looking untidy.

It readily self seeds and its rhizomatous roots mean that it can be an aggressive spreader and difficult to eradicate once established. If you’re not careful, the leafy mounds could quickly take over your entire garden. Some regions classify it as an invasive species. If you do plan to plant goutweed, you might want to contain it to spots where other plants struggle to survive.

There’s a variegated variety of the plant that is known for being less invasive, and this tends to be the most popular choice in gardens.

The plant’s ability to grow in shady locations and a wide variety of soil types, make it a good option for cover under a group of trees. The spreading roots system can be helpful if you’re looking for plants to help tackle steep-sided soil erosion.

Botanical Name Aegopodium podagraria
Common Name Goutweed, cow parsley, ground elder
Plant Type Herbaceous, perennial
Mature Size Flowering stems can grow to be up to 1m tall
Sun Exposure Full sun, partial shade, full shade
Soil Type Well-drained
Soil pH Acid, neutral, alkaline
Bloom Time Summer
Flower Color White
Hardiness Zones 4-9 (USDA)
Native Area Europe, Asia

Goutweed Care

A lover of damp and shady conditions, goutweed is adaptable and can handle most soil types, urban pollution, and different moisture levels. This can be a blessing and a curse. It’ll grow where other plants won’t, but it can also take over your garden space in no time if not kept in check.

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